1 CONFORMATIONAL STABILITY OF HELICOBACTER PYLORI FLAVODOXIN . FIT TO FUNCTION AT pH
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CONFORMATIONAL STABILITY OF HELICOBACTER PYLORI FLAVODOXIN. FIT TO FUNCTION AT pH 5. Nunilo Cremades, Marta Bueno, José Luis Neira, Adrián Velázquez-Campoy, & Javier Sancho Biocomputation and Complex Systems Physics Institute (BIFI), Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza. 50009 Zaragoza, Spain. Instituto de Biología Molecular y Celular, Universidad Miguel Hernández. 03202 Elche, Alicante, Spain. Address correspondence to: Javier Sancho, Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza. 50009 Zaragoza, Spain, Phone: 34 976761286, FAX: 34 976762123 . E-mail: [email protected]
منابع مشابه
1 CONFORMATIONAL STABILITY OF HELICOBACTER PYLORI FLAVODOXIN . FIT TO FUNCTION AT pH 5
CONFORMATIONAL STABILITY OF HELICOBACTER PYLORI FLAVODOXIN. FIT TO FUNCTION AT pH 5. Nunilo Cremades, Marta Bueno, José Luis Neira, Adrián Velázquez-Campoy, & Javier Sancho Biocomputation and Complex Systems Physics Institute (BIFI), Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza. 50009 Zaragoza, Spain. Instituto de Biología Molecular y ...
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Flavodoxin is an essential protein for Helicobacter pylori, a pathogen living in the very acidic environment of the gastric tract and responsible for several diseases. We report the conformational stability of the protein in neutral and acidic pH. The apoprotein remains native between pH 12 and 5 and adopts a monomeric molten globule conformation at more acidic pH values. The equilibrium unfold...
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The redox protein flavodoxin has been shown earlier to be reduced by the pyruvate-oxidoreductase (POR) enzyme complex of Helicobacter pylori, and also was proposed to be involved in the pathogenesis of gastric mucosa-associated lymphoid-tissue lymphoma (MALToma). Here, we report its X-ray structure, which is similar to flavodoxins of other bacteria and cyanobacteria. However, H. pylori flavodox...
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The catabolic pathway for flavodoxin has yet to be clarified for any bacterial species. In this study, we found that the flavin mononucleotide in the flavodoxin of Helicobacter pylori is degraded to riboflavin via the phosphomonoesterase activity of class C acid phosphatase. The result is a conversion of holoflavodoxin to apoflavodoxin.
متن کاملTowards a new therapeutic target: Helicobacter pylori flavodoxin.
Helicobacter pylori flavodoxin is the electronic acceptor of the pyruvate-oxidoreductase complex (POR) that catalyzes pyruvate oxidative decarboxilation. Inactivation of this metabolic route precludes bacterial survival. Because flavodoxin is not present in the human host, substances interfering electronic transport from POR might be well suited for eradication therapies against the bacterium. ...
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تاریخ انتشار 2007